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CLOZARIL® (clozapine) tablets, for oral use - Initial Table of Contents BOXED WARNING (What is this?) WARNING: SEVERE NEUTROPENIA; ORTHOSTATIC HYPOTENSION, BRADYCARDIA, AND SYNCOPE; SEIZURE; MYOCARDITIS AND CARDIOMYOPATHY; INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSIS Severe Neutropenia Published online 2022 Jun 27 doi: 10 1007 s40263-022-00932-2 PMCID: PMC9243911 PMID: 35759211 A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia --- drugs com clozaril htmlClozapine appears to have superior effects on positive, negative, and overall symptoms and relapse rates in schizophrenia (treatment-resistant and non-treatment-resistant subpopulations) compared dailymed nlm nih gov dailymed drugInfo cfmClozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics or who have been unable to tolerate other drugs due to extrapyramidal side effects Clozapin ist ein potenter Antagonist an α 1 -Adrenozeptoren, muskarinischen Acetylcholin M 1 -Rezeptoren, Serotonin-Rezeptoren (insbesondere 5-HT 2A - und 5-HT 2C -Rezeptoren) sowie Histamin H 1 -Rezeptoren Von besonderem Interesse ist die Wechselwirkung von Clozapin mit Dopamin-Rezeptoren --- ncbi nlm nih gov pmc articles PMC9243911Clozapine: MedlinePlus Drug Information Home → Drugs, Herbs and Supplements → Clozapine pronounced as (kloe' za peen) Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?medlineplus gov druginfo meds a691001 htmlClozaril is an antipsychotic medicine It works by changing the actions of chemicals in the brain Clozaril is used to treat schizophrenia in adults after other treatments have failed Clozaril is available only from a certified pharmacy under a special program de wikipedia org wiki ClozapinDrugs & Supplements Clozapine (Clozaril) Brand Names: Clozaril, FazaClo, Versacloz Clozapine is an antipsychotic medicine that is used in adults to treat schizophrenia after other treatments --- nature com articles s41398-021-01613-2--- netdoktor de medikamente clozapinClozapin ist ein sogenanntes Antipsychotikum Es wird bei Schizophrenie angewendet, wenn andere Medikamente nicht wirken oder nicht vertragen werden, sowie bei Psychosen im Verlauf eines Morbus Parkinson, wenn die Standardtherapie versagt Vor Behandlungsbeginn und im Verlauf muss sichergestellt sein, dass das Blutbild des Patienten in Ordnung ist en wikipedia org wiki Clozapine--- ncbi nlm nih gov pmc articles PMC3999500--- everydayhealth com drugs clozapineIt was not until fourteen years after its withdrawal that the results of the pivotal US Clozaril Study were published and the important role of clozapine in clinical practice was discovered Clozapine demonstrated superiority to chlorpromazine in treatment-resistant patients in many outcomes including treatment response, with improvements in positive and negative symptoms of schizophrenia [ 2 ]
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