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Rapid oral transmucosal delivery of zaleplon-lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation Drug Deliv 2022 Dec;29(1):2773-2783 doi: 10 1080 10717544 2022 2115165 --- semanticscholar org paper 4c29f2d393c1f1dfa346005728c271d361dc94c1This investigation revealed that ZP-LV-SNELTs delivered zaleplon with enhanced solubility, a fast release, and boosted bioavailability thru oral mucosa which provided a favorable route for drug administration Abstract Based on the administration convenience, transmucosal buccal drug delivery allows special strength points over peroral routes for systemic delivery It could achieve local or Insomnia is a highly prevalent disorder in the US and worldwide Insomnia is defined as the presence of long sleep latency, frequent nocturnal awakenings, or prolonged periods of wakefulness during the sleep period, or even frequent transient arousals Zaleplon is a medication used in the management and treatment of insomnia It is in the hypnotic class of drugs but is unrelated to --- researchgate net 305751805_A_Review_of_Novel_Formulation_Strategies_t --- researchgate net 363053251_Rapid_oral_transmucosal_delivery_of_zalepl Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class [5] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999 The main goal of the current investigation was to develop and optimize lavender oil–based nanoemulsions loaded with zaleplon and incorporate the optimum formulation into fast-disintegrating tablets to boost the bioavailability and onset of action of the ZP and administering the developed optimal paradigms via the advantageous transmucosal buccal route as Zaleplon Microparticles Delivery Systems Carmen Popescu 1, Prashanth Manda 2, Rana AC Fast dissolving films: a novel approach to oral drug delivery Int Res J Pharm 2011;2:69–74 Overall a 3 5-fold enhancement in the extent of absorption of zaleplon from SNEP-N formulation proves the feasibility of SNEPs formulation for improved oral delivery of zaleplon View Show abstract--- researchgate net Oral-Disintegrating-Tablets-ODT-and-Oral-Dissolving- link springer com article 10 1208 s12249-017-0924-9--- ncbi nlm nih gov books NBK551571en wikipedia org wiki Zaleplon--- ncbi nlm nih gov pmc articles PMC9429977--- ncbi nlm nih gov pmc articles PMC3932650pubmed ncbi nlm nih gov 36036168In a systematic review of the literature of driving studies involving a variety of sleeping agents (n = 14 studies), differences in driving ability by gender were noted the morning after taking a sleeping agent for flurazepam 30 mg and zolpidem 10 mg administered in the middle of the night, but not for ramelteon 8 mg, lormetazepam 1 and 2 mg, zaleplon 10 and 20 mg, and zopiclone 7 5 mg PDF | Based on the administration convenience, transmucosal buccal drug delivery allows special strength points over peroral routes for systemic | Find, read and cite all the research you need The following research study focuses on improving the solubility of zaleplon (BCS class II drug) via micronization technique in order to enhance its oral delivery in orodispersible formulations Zaleplon along with a surfactant solution was micronized by ultrasonication The micronization process reduced the particle size of the crystalline drug about six-fold from its original size of 155 5
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