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--- dovepress com association-of-hypertension-and-breast-cancer-antihyper --- thelancet com journals lanonc article PIIS1470-2045(21)00033-4 fulltextcancer? Evidence from recent observational studies Drugs Aging 1998; 13:99–108 Response We appreciate the comments of Dr Goldstein regarding the incidence of cancer seen with amlodipine in the Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) 1 Because of the concern raised by Pahor et al,2 we--- health harvard edu ask-the-doctor-calcium-channel-blockers-and-cancer --- ahajournals org doi pdf 10 1161 01 cir 104 2 e5To the Editor: The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) 1 amplifies the controversy over calcium antagonists and increased cancer risk 2 In this 36-month, placebo-controlled, randomized trial, the calcium antagonist amlodipine had no effect on the angiographic progression of coronary atherosclerosis or on the risk of major cardiovascular events breast-cancer-research biomedcentral com articles 10 1186 s13058-016-0720-6Background In a recent case–control study, long-term use of calcium channel blocking drugs was associated with a greater-than-twofold increased breast cancer risk If prospectively collected data confirm that calcium channel blocker use increases breast cancer risk, this would have major implications for hypertension treatment The objective of this study was to determine whether women using --- ahajournals org doi full 10 1161 01 cir 104 2 e5It's true that a large study found that women who took calcium-channel blockers (CCBs) for 10 years or longer had more than double the odds of having certain forms of breast cancer, including the most common type, invasive ductal breast cancer Common examples of CCBs include amlodipine (Norvasc), felodipine (Plendil), nifedipine (Adalat), and Controversy exists regarding the potential association between taking calcium channel blockers (CCBs) and the development of breast cancer As a positive association would have important public health implications due to the widespread use of CCBs, this study aimed to incorporate new evidence to determine whether an association is likely to exist pubmed ncbi nlm nih gov 28866282Β-Blockers (BBs) and BC BB drug therapy reduces secondary cancer formation and improves cancer-specific survival in breast cancer Compared to non-hypertensive breast cancer patients or those treated with other antihypertensive drugs, patients who started and maintained antihypertensive beta-blocker therapy prior to their breast cancer diagnosis had fewer distant metastases 41 BBs may also Furthermore, we found no consistent evidence that the use of any antihypertensive drug class had a material effect on the risk of developing breast, colon, lung, prostate, or skin cancer We found no association between risk estimates and longer durations of treatment (up to 4 years on average)
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