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onlinelibrary wiley com doi full 10 2164 jandrol 111 015230Erectile dysfunction (ED), formerly known as impotence, is a condition that affects roughly 40% of people with penises over the age of 40 and 70% over the age of 70 One of the critical risk factors for ED is high cholesterol Some studies suggest that seven of every 10 people with ED meet the clinical definition of high cholesterol (also known --- verywellhealth com statins-and-erectile-dysfunction-5211922The association between ED and statins was evaluated by calculating the reporting odds ratio (ROR) of exposure to each drug and its 95% confidence interval Among the spontaneous reports selected (110 685), exposure to statins was identified in 4471 cases (4%), among which, 51 (1 1%) had ED, whereas 431 (0 4%) cases of ED were found among the remaining 106 214 reports not exposed to statins pubmed ncbi nlm nih gov 22052777--- ncbi nlm nih gov pmc articles PMC4304928The outcome measure was the IIEF-5 score (normal erectile function, 22–25; mild ED, 17–21; mild to moderate ED, 12–16; moderate ED, 8–11; and severe ED --- amjmed com article S0002-9343(17)31125-7 fulltextED has not been reported in the major randomized double blind trials of lipid-lowering therapy, and on this basis the causative link has been disputed 19 However, large trials of both fibrates and statins failed to find this adverse effect despite the fact that evidence from other sources for ED, following fibrate therapy at least, is strong Testosterone is the primary male sex hormone, and it’s necessary for an erection to be achieved The same study also pointed to the possibility that statins can aggravate existing ED However, a --- ncbi nlm nih gov pmc articles PMC4023379Statins were associated with 3 4 units (95% confidence interval [CI], 1 7–5 0; p=0 0001) improvement compared to control Limitations of this study, mentioned in our report, were the small number of subjects (713 patients) included the analysis, the short duration of follow-up, median 3 months, mean 4 2±3 months, as well as possible publication bias, and incomplete adjustment for confounders --- healthline com health do-statins-cause-erectile-dysfunctionMoreover, statins are universally considered a key element of secondary prevention for vascular events; therefore, several points are opened In this critical summary, we attempt to evaluate the effects of statins on ED and to understand the mechanisms through which statins improve the quality of erection and the possible synergism with V phosphodiesterase inhibitors, drugs largely used for --- ncbi nlm nih gov pmc articles PMC6305857academic oup com fampra article 19 1 95 555569onlinelibrary wiley com doi full 10 1111 and 14408Atorvastatin may be an effective treatment for erectile dysfunction (ED) The purpose of this meta-analysis was to determine whether atorvastatin therapy is effective in the treatment of ED All published research on atorvastatin in the treatment of ED patients in EMBASE, PubMed, Web of Science and Cochrane were investigated till 30 October 2021 Several studies have associated statins with sexual and gonadal dysfunction, including ED, lower testosterone levels, and decreased libido 9-11 On the other hand, statins ameliorate endothelial dysfunction and increase nitric oxide bioavailability, which can improve ED 12-14 Furthermore, the antiinflammatory properties of statins may result in a decreased risk for the development of BPH Three randomized trials and 3 observational studies were identified, with 69,448 men, of whom 24,661 were statin users Statin use was not associated with an increased risk of new onset of erectile dysfunction by random effects model or fixed effect model (risk ratio 0 96; 95% confidence interval, 0 84-1 10; P = 58; and odds ratio 0 95; 95% confidence interval, 0 88-1 02; P = 20, respectively)
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