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Conclusion Wellbutrin may be an option for adults with ADHD who don’t respond well to stimulants or have co-occurring mental health conditions Wellbutrin is the brand name for the Bupropion may lead to a small improvement in ADHD and it may also decrease symptoms related to ADHD The drug does not have more adverse effects than treatment with placebo Bupropion may be an alternative treatment for adults with ADHD who cannot or will not take stimulant drugs Quality of the evidence Description of the condition Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurobiological condition, which persists throughout the lifespan, affecting an estimated 6% of adolescents and 3% to 4% of adults ( Fayyad 2007 ) ADHD is characterised by problems of inattention, impulsivity and excessive activity, and is commonly --- additudemag com wellbutrin-for-adhd--- ncbi nlm nih gov pmc articles PMC6483732--- ncbi nlm nih gov pmc articles PMC6485546--- cochrane org BEHAV_bupropion-attention-deficit-hyperactivity-disorder --- ncbi nlm nih gov pmc articles PMC2416755pubmed ncbi nlm nih gov 27813651The three head-to-head trials found that bupropion had efficacy comparable to methylphenidate (p > 0 05) However, a large double-blind, placebo-controlled multicenter study of bupropion found smaller effect sizes for bupropion, as quantified using teacher and parent ratings of ADHD symptoms, than methylphenidate --- medicalnewstoday com articles 325791pubmed ncbi nlm nih gov 28965364Wellbutrin Dosages for ADHD A typical daily dose is around 150 mg per day, although the starting dose is often lower For ADHD, clinical trials suggest that a dose of between 150 mg and 450 mg per day can be helpful --- verywellmind com using-wellbutrin-for-adhd-4137671Bupropion may be an alternative treatment for adults with ADHD who cannot or will not take stimulant drugs Quality of the evidence The quality of the evidence in this review is low, because we found very few studies; five of the six studies were small, and all were poorly conducted The effect of bupropion on various aspects of daily Abstract Increased attention has been given to the alternatives to stimulants in the treatment of attention deficit hyperactivity disorder (ADHD) in both adults and children This short-term, double-blind trial was designed to evaluate the extended-release form of bupropion in adult subjects meeting DSM-IV and the Utah Diagnostic Criteria for Since then, it has been used to treat seasonal affective disorder (SAD) and help minimize nicotine cravings when stopping smoking Although it is classified as an anti-depressant, Wellbutrin enhances actions that impact dopamine and norepinephrine in the brain, so today it is also commonly prescribed as an “off-label” treatment for ADHD Thus, alternative non-stimulant treatment approaches for ADHD have been explored One of these alternatives is bupropion, an aminoketone antidepressant and non-competitive antagonism of nicotinic acetylcholine receptors Bupropion is registered for the treatment of depression and smoking cessation, but is also used off-label to treat ADHD --- healthline com health wellbutrin-for-adhdWellbutrin also increased the proportion of participants who experienced a significant improvement in ADHD symptoms People who took Wellbutrin were 50% more likely to improve compared to people
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