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Atomoxetin Følgende præparater indeholder indholdsstoffet Atomoxetin : Præparat Dispenseringsform styrke Andre indholdsstoffer Atomoxetin "Glenmark" Glenmark Nordic hårde kapsler 10 mg hårde kapsler 18 mg hårde kapsler 25 mg go drugbank com drugs DB00289Atomoxetine, N-desmethylatomoxetine, and 4-hydroxyatomoxetine produce minimal to no inhibition of CYP1A2 and CYP2C9, but inhibit CYP2D6 in human liver microsomes at concentrations between 3 6 and 17 μmol L [citation needed] Plasma concentrations of 4-hydroxyatomoxetine and N-desmethylatomoxetine at steady state are 1 0% and 5% that of atomoxetine in CYP2D6 extensive metabolizers, and are 5% Side Effects Associated with Atomoxetine The most common side effects of Atomoxetine are as follows: Children and adolescents (ages 6 – 17): upset stomach, decreased appetite, nausea, and vomiting Adults: constipation, dry mouth, nausea, decreased appetite, dizziness, sexual side effects, and problems passing urine en wikipedia org wiki Atomoxetine--- additudemag com medication atomoxetine-hydrochloridepro medicin dk Medicin Praeparater 9093Note: Atomoxetine is an ocular irritant; if capsule is opened inadvertently and contents come into contact with eye, flush eye immediately with water and obtain medical advice; wash hands and any potentially contaminated surface as soon as possible Storage Store at 25°C (77°F); excursions are permitted between 15°C and 30°C (59°F and 86°F) Biotilgængelighed 63-94 % Maksimal plasmakoncentration efter 1-2 timer Metaboliseres i leveren via CYP2D6 til en farmakologisk ækvipotent metabolit, 4-hydroxyatomoxetin Plasmahalveringstid ca 3,5 timer (atomoxetin), men er afhængig af CYP2D6-genotype Udskilles primært som 4-hydroxyatomoxetin gennem nyrerne Atomoxetine "Stada" må ikke tages, hvis man inden for de sidste 14 dage har været i behandling med MAO-hæmmere (midler mod depression eller Parkinsons sygdom) Atomoxetine "Stada" kan nedsætte virkningen af midler mod forhøjet blodtryk og øge blodtrykket, hvis det gives sammen med visse andre midler, bl a salbutamol (middel mod astma) Atomoxetine is indicated for treating attention deficit hyperactivity disorder (ADHD) in adults and children over six years Although atomoxetine is only FDA-approved for treating ADHD, it is sometimes used off-label to treat adult patients with treatment-resistant depression This activity outlines the indications, mechanism of action, administration, adverse effects, contraindications, and Common atomoxetine side effects Common atomoxetine side effects may include nausea, vomiting, upset stomach, constipation, dry mouth, loss of appetite, mood changes, feeling tired, dizziness, urination problems, or impotence, which is trouble having an erection Atomoxetine is not approved for major depressive disorder Pooled analyses of short-term (6 to 18 weeks) placebo-controlled trials of atomoxetine in children and adolescents (a total of 12 trials involving over 2200 patients, including 11 trials in ADHD and 1 trial in enuresis) have revealed a greater risk of suicidal ideation early during treatment in those receiving atomoxetine compared to Absorption The pharmacokinetic profile of atomoxetine is highly dependent on cytochrome P450 2D6 genetic polymorphisms of the individual 1 A large fraction of the population (up to 10% of Caucasians and 2% of people of African descent and 1% of Asians) are poor metabolizers (PMs) of CYP2D6 metabolized drugs --- medicine com drug atomoxetine hcp--- drugs com atomoxetine htmlmin medicin dk Medicin Praeparater 9103--- rxwiki com atomoxetinepro medicin dk Medicin Indholdsstoffer 3307--- ncbi nlm nih gov books NBK493234
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