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We noted the recent information in the Journal about metoclopramide use and its risk of neurologic adverse effects such as tardive dyskinesia 1,2 Shaffer et al 1 noted that metoclopramide was often used for more than 30 days and that use was “notably high in children under 10 years of age ” However, the exact number of children who had adverse reactions reported to the Food and Drug --- researchgate net 326880724_Metoclopramide_A_Safe_Alternative_to_Dompe However, it carries a black box warning, as it is generally not well-tolerated and chronic use (>12 weeks) may lead to extrapyramidal side effects and potential irreversible tardive dyskinesia, which has been reported in a small percentage of case reports 14, 15 Domperidone is a peripherally acting dopamine-2 antagonist that decreases nausea, corrects gastric dysrhythmias, and increases Metoclopramide: A Safe Alternative to Domperidone? A Case Report on Severe Cardiac Adverse Effects in an Older Patient Peripheral antidopaminergic medication is frequently prescribed to treat nausea However, domperidone is ill-famed for its severe cardiac adverse effects Metoclopramide has been suggested as a relatively safe alternative because it has long been considered to have less significant cardiovascular ad …link springer com article 10 1007 s40800-018-0090-3The anti-emetic drug domperidone (Motilium - Janssen) was introduced in 1982 1 Like metoclopramide the drug blocks dopamine receptors in the medullary chemoreceptor trigger zone, thereby influencing the central control of nausea and vomiting, and in the gut to increase gastrointestinal motility 2 Parenteral domperidone which was used to prevent vomiting caused by cytotoxic drugs or 24 Page 2 of 3 L C Sijtsma et al registered,butweassumeaslowspeed(overatleast3min) in accordance with the hospital protocol Shortly afterwards, sheturnedpale pubmed ncbi nlm nih gov 30088117link springer com content pdf 10 1007 s40800-018-0090-3 pdfdtb bmj com content 26 15 59Peripheral antidopaminergic medication is frequently prescribed to treat nausea However, domperidone is ill-famed for its severe cardiac adverse effects Metoclopramide has been suggested as a relatively safe alternative because it has long been considered to have less significant cardiovascular adverse effects We present an older patient who developed severe bradycardia and hypotension europepmc org article PMC PMC6081487--- ncbi nlm nih gov pmc articles PMC6284339--- japha org article S1544-3191(15)31663-0 fulltextHowever, domperidone is ill-famed for its severe cardiac adverse effects Metoclopramide has been suggested as a relatively safe alternative because it has long been considered to have less
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