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rastolih

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Mittwoch, 3. April 2024, 07:00

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The present study was undertaken to investigate the effects of transdermal clonidine, an α-2 adrenergic receptor agonist that suppresses sympathetic nervous system activity 8 on glucose metabolism; and to examine risk factors in patients with both diabetes and hypertension --- ncbi nlm nih gov pmc articles PMC6049816Co-treatment with clonidine and a GRK2 inhibitor prevented Type 2 diabetes mellitus (DM), and hypertension often occur simultaneously [1, 2] In addition, there is generalClonidine, a centrally acting α 2 ‐adrenoceptor agonist, has neuroendocrine effects, including inhibition of sympathoadrenal activity We therefore evaluated the effect of clonidine on blood glucose control and insulin requirements during ophthalmic surgery when given as premedication in type 2 diabetic patients Methods Hypertension and diabetes are associated with a risk of cardiovascular disease Clonidine is currently used as a fourth-line drug therapy for hypertension because of its rebound hypertensive link springer com article 10 1007 BF03348472--- nature com articles s41440-018-0016-6academic oup com ajh article 11 2 184 136931Clonidine has been reported to adversely affect glucose tolerance in experimental animals and normal man We assessed its short- and long-term effects in 10 patients In contradiction to these reports, beneficial effects of clonidine on glycemic control such as prevention of insulin resistance and diabetes induced hyperglycemia have also been reported [13,14] Meanwhile in our study, treatment with clonidine has significantly increased the blood glucose in alloxan -induced diabetic rats Clonidine was given for a variety of etiologies including irritable bowel syndrome, diabetes, withdrawal-associated diarrhea, neuroendocrine tumors, intestinal failure, and cholera Collectively, these studies demonstrated a strong effect of clonidine on diarrhea with a decrease in stool volume by 0 97 l per day, a decrease in stool frequency by 0 4 times day, and an increase in transit time --- nature com articles s41440-018-0016-6 pdfThe authors investigated the effects of clonidine (alpha-2 stimulating agent) on blood glucose, insulin and glucagon levels in order to assess the alpha-adrenergic regulation of endocrine pancreatic secretion Ten hypertensive female subjects affected with type 2 diabetes were studied; each subject …ascpt onlinelibrary wiley com doi pdf 10 1038 clpt 1983 239--- ncbi nlm nih gov pmc articles PMC2812780The authors investigated the effects of Clonidine (α-2 stimulating agent) on blood glucose, insulin and glucagon levels in order to assess the α-adrenergic regulation of endocrine pancreatic secretion Ten hypertensive female subjects affected with type 2 diabetes were studied; each subject was given a protein meal (boiled beef 200 g); blood samples were taken at −30,0,30, 60, 90 and 120 academic oup com bja article 90 4 434 274300pubmed ncbi nlm nih gov 3897355
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